Oestradiol valerate, also known as estradiol valerate, is a medication used in hormone replacement therapy (HRT) for the treatment of symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood changes. It is a synthetic form of estradiol, which is the primary female sex hormone produced by the ovaries.

Oestradiol valerate is typically administered orally or via injection. Once in the body, it is converted into estradiol, which then helps to alleviate menopausal symptoms by restoring hormonal balance. Additionally, oestradiol valerate may be used in transgender hormone therapy to feminize the body by promoting the development of female secondary sexual characteristics.