Alpha keto analogues (AKAs) are synthetic compounds that are structurally similar to amino acids, the building blocks of proteins. They are used in the management of chronic kidney disease (CKD) and other conditions associated with protein metabolism disorders.

AKAs are often prescribed as dietary supplements for individuals with CKD who are undergoing conservative management or dialysis. These compounds are designed to provide essential amino acids without the burden of excess nitrogen, which can be difficult for individuals with impaired kidney function to excrete.