Polymyxin B is an antibiotic drug derived from the bacteria Bacillus polymyxa. It is primarily used to treat infections caused by gram-negative bacteria, including E. coli, Klebsiella, and Pseudomonas. It is used as an injectable and topically as eyed drops, ear drops, cream. It can be used alone or in combination with other antibiotics.

Side Effects:

Polymyxin B can cause side effects, like any medication. The most common side effects are:

• Local irritation

• Allergic reactions

• Nephrotoxicity (toxicity to kidneys)

• Neurotoxicity (toxicity to nerves)

Other less common side effects include:

• Respiratory distress

• Cardiac dysrhythmias (irregular heartbeats)

• Anemia (low red blood cells)

• Decrease of platelets in blood

It’s important to know that these side effects are not necessarily common or will be experienced by everyone who takes this medication, but it’s important to be aware of them. It’s important to consult with healthcare provider and follow the instructions of use and dosing. If any serious side effects occur, contact immediately healthcare provider.

Polymyxin B should be used with caution in individuals with a history of kidney or nerve disease, as it may worsen these conditions. Also, is important to know that it has a low efficacy against many common pathogenic bacteria and it has been replaced by other antibiotics in most cases.