Imipenem and cilastatin is a combination medication used to treat severe bacterial infections. Imipenem is a broad-spectrum antibiotic belonging to the carbapenem class, while cilastatin is an inhibitor of the enzyme dehydropeptidase-I.

Imipenem works by inhibiting the synthesis of bacterial cell walls, leading to bacterial cell death. It is effective against a wide range of bacteria, including both gram-positive and gram-negative bacteria.

Cilastatin, on the other hand, prevents the breakdown of imipenem in the kidneys, allowing it to remain active in the body for a longer period of time. This enhances the effectiveness of imipenem and reduces the risk of kidney damage associated with its use.

Imipenem and cilastatin are typically administered together intravenously in a hospital setting to treat serious infections such as pneumonia, urinary tract infections, intra-abdominal infections, and sepsis. It’s important to use this medication as directed by a healthcare professional and to complete the full course of treatment, even if symptoms improve before the medication is finished. Common side effects may include diarrhea, nausea, vomiting, and skin rash. If you experience severe or persistent side effects, it’s essential to contact your doctor promptly.