D-CORT INJECTION 25x1ML

D-CORT INJECTION 25x1ML contains Dexamethasone Sodium, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. It is a water-soluble form of dexamethasone commonly used in medical settings for its anti-inflammatory effects.

Uses:

1. Inflammatory Conditions: D-CORT INJECTION is prescribed for the treatment of various inflammatory conditions such as allergic reactions, asthma exacerbations, rheumatic disorders, and dermatological conditions like eczema and psoriasis.
2. Immunosuppression: It is also utilized to suppress the immune response in conditions like autoimmune diseases and organ transplantation.
3. Cerebral Edema: Dexamethasone may be used to reduce cerebral edema associated with brain tumors or brain injury.

Mechanism of Action:

Dexamethasone exerts its pharmacological effects by binding to cytoplasmic glucocorticoid receptors, leading to the activation or repression of multiple genes involved in inflammation and immune response regulation. It suppresses the production of inflammatory mediators such as prostaglandins and leukotrienes, inhibits the migration of inflammatory cells, and reduces capillary permeability, thereby mitigating inflammation and immune responses.

Dosage and Administration:

The dosage of D-CORT INJECTION varies depending on the condition being treated, the patient’s age, weight, and response to therapy. It is typically administered intravenously or intramuscularly, and the dosage may be adjusted based on the severity of the condition and individual patient factors. Dexamethasone should be used at the lowest effective dose for the shortest duration necessary to achieve the desired therapeutic outcome.

Precautions:

1. Immunosuppression: Prolonged use of D-CORT INJECTION may lead to immunosuppression, increasing the risk of infections. Patients should be monitored for signs of infection during treatment.
2. Adrenal Suppression: Long-term use of glucocorticoids like dexamethasone can suppress adrenal gland function, necessitating gradual dose tapering to avoid adrenal insufficiency upon discontinuation.
3. Hyperglycemia: Dexamethasone may cause hyperglycemia or worsen existing diabetes. Blood glucose levels should be monitored in diabetic patients receiving treatment.
4. Osteoporosis: Chronic glucocorticoid therapy is associated with an increased risk of osteoporosis and fractures. Adequate calcium and vitamin D intake, along with regular bone density monitoring, may be necessary.

Side Effects:

Common side effects of D-CORT INJECTION include fluid retention, electrolyte imbalance, hypertension, gastrointestinal upset, insomnia, mood changes, and increased susceptibility to infections. Long-term use or high doses may lead to more serious adverse effects such as Cushing’s syndrome, osteoporosis, glaucoma, and adrenal suppression.

In Summary:

D-CORT INJECTION containing Dexamethasone Sodium is utilized for its potent anti-inflammatory and immunosuppressive effects in various inflammatory and autoimmune conditions. It acts by modulating gene expression and inhibiting inflammatory pathways, thereby reducing inflammation and immune responses.