MIKARAY 150MG/2ML INJECTION

MIKARAY 150MG/2ML INJECTION contains Amikacin Sulphate as its active ingredient. It is a potent antibiotic belonging to the aminoglycoside class, primarily used for the treatment of severe bacterial infections caused by susceptible organisms. Amikacin works by inhibiting bacterial protein synthesis, leading to the disruption of bacterial cell growth and ultimately causing bacterial cell death.

Mechanism of Action:

Amikacin Sulphate exerts its antibacterial effects by irreversibly binding to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis. This inhibition leads to the accumulation of non-functional or toxic peptides within the bacterial cell, ultimately causing cell death. Amikacin has a broad spectrum of activity against Gram-negative bacteria, including strains resistant to other antibiotics.

Uses:

MIKARAY 150MG/2ML INJECTION is indicated for the treatment of serious infections caused by susceptible organisms, including:

• Lower respiratory tract infections (such as pneumonia)
• Urinary tract infections
• Septicemia
• Skin and soft tissue infections
• Bone and joint infections
• Intra-abdominal infections
• Meningitis (as adjunctive therapy)
• Neonatal infections (such as sepsis and pneumonia)

Dosage and Administration:

The dosage of MIKARAY 150MG/2ML INJECTION is determined based on the severity of the infection, the patient’s weight, renal function, and susceptibility of the causative organism. It is administered intramuscularly or intravenously. The injection should be given slowly over a period of 30 to 60 minutes to minimize the risk of adverse effects.

Side Effects:

Common side effects associated with MIKARAY injection may include:

• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss, balance disorders)
• Neurotoxicity (muscle weakness, tingling sensation)
• Injection site reactions (pain, irritation)
• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Allergic reactions (rash, itching, swelling)
• Blood disorders (e.g., thrombocytopenia)
• Electrolyte disturbances (e.g., hypomagnesemia, hypokalemia)

Precautions:

• MIKARAY 150MG/2ML INJECTION should be used with caution in patients with pre-existing renal impairment or hearing impairment, as dosage adjustments may be necessary.
• Monitoring of renal function, hearing, and serum amikacin levels is recommended during treatment to minimize the risk of adverse effects.
• Patients should be monitored for signs of neurotoxicity, such as muscle weakness or tingling sensations, especially with prolonged therapy or in patients with compromised renal function.
• MIKARAY injection should not be co-administered with other potentially nephrotoxic or ototoxic drugs unless absolutely necessary.

Conclusion:

MIKARAY 150MG/2ML INJECTION, containing Amikacin Sulphate, is a valuable antibiotic used for the treatment of severe bacterial infections. By inhibiting bacterial protein synthesis, it effectively eradicates susceptible pathogens, improving patient outcomes in various clinical settings.