SITAPHAGE XR 50/1000MG TABLET

SITAPHAGE XR 50/1000MG TABLET is a combination medication used to manage Type 2 Diabetes Mellitus. It contains two active ingredients: Sitagliptin & Metformin. SITAPHAGE XR is an extended-release (XR) formulation, meaning it releases the medication slowly over time, allowing for more stable blood sugar control throughout the day.

• Sitagliptin is a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor) that works by increasing the levels of incretin hormones, which help regulate blood sugar by stimulating insulin release and reducing the amount of glucose produced by the liver.
• Metformin is a biguanide that works by reducing the amount of sugar the liver produces and helping muscle cells become more sensitive to insulin, thereby improving overall glucose uptake and lowering blood sugar levels.

Together, these two ingredients work synergistically to control blood sugar, improving insulin sensitivity and reducing excessive glucose production.

SITAPHAGE XR 50/1000MG is typically prescribed to people with Type 2 diabetes who are unable to achieve adequate blood sugar control with diet and exercise alone. This combination drug is usually taken once daily, making it convenient for patients to manage their diabetes.

Uses:

• Type 2 Diabetes Mellitus: SITAPHAGE XR is used to control blood sugar levels in patients with Type 2 diabetes, typically when lifestyle changes such as diet and exercise are not enough. It helps manage both fasting and postprandial (after meal) blood sugar levels.
• Adjunct to Diet and Exercise: This medication is used in combination with a healthy diet and regular exercise to improve glycemic control in adults.
• Combination Therapy: SITAPHAGE XR may be prescribed as part of a combination therapy with other antidiabetic drugs, such as insulin or sulfonylureas, for better blood sugar management.

Side Effects:

Like all medications, SITAPHAGE XR may cause side effects, though not everyone experiences them. The most common side effects include:

• Gastrointestinal Issues:
  • Nausea, vomiting, diarrhea, abdominal discomfort, or bloating.
  • These side effects are more likely to occur at the beginning of treatment and may improve over time.
• Hypoglycemia (Low Blood Sugar):
  • While Sitagliptin has a low risk of causing hypoglycemia, there is a higher risk if it is combined with other medications, such as insulin or sulfonylureas.
  • Symptoms of hypoglycemia include sweating, shaking, confusion, dizziness, and weakness.
• Headache or dizziness may occur, particularly during the initial phase of treatment.
• Weight Neutrality or Weight Loss: Metformin generally does not cause weight gain and may even result in modest weight loss, which can be beneficial for overweight patients with Type 2 diabetes.

Serious Side Effects (rare but require immediate attention):

• Lactic acidosis: A rare but serious side effect of Metformin, which is a medical emergency. Symptoms include muscle pain, weakness, difficulty breathing, and irregular heartbeat.
• Pancreatitis: In rare cases, Sitagliptin has been associated with pancreatitis (inflammation of the pancreas). Symptoms of pancreatitis include severe abdominal pain, nausea, and vomiting.
• Allergic reactions: Some patients may experience allergic reactions, including rash, itching, or swelling, especially around the face, lips, or throat.

Precautions:

1. Kidney Function:
   • Sitagliptin and Metformin are both excreted through the kidneys, so it is important to assess kidney function before starting SITAPHAGE XR and periodically during treatment.
   • In patients with renal impairment, the dosage may need to be adjusted, or the drug may be contraindicated.
2. Liver Disease:
   • People with liver disease should be cautious when taking SITAPHAGE XR. Metformin, in particular, should not be used in patients with significant liver impairment due to the risk of lactic acidosis.
3. Lactic Acidosis:
   • Patients at higher risk of lactic acidosis include those with severe kidney impairment, liver disease, or a history of alcohol abuse. Symptoms of lactic acidosis require immediate medical attention.
4. Heart Failure and Cardiovascular Disease:
   • While SITAPHAGE XR does not have a direct contraindication in patients with heart failure, caution should be used, especially in those with a history of heart disease or who are on multiple medications.
5. Pregnancy and Breastfeeding:
   • Pregnancy: SITAPHAGE XR is not recommended during pregnancy. If you are pregnant or planning to become pregnant, consult your doctor to discuss alternative options.
   • Breastfeeding: It is not known whether SITAPHAGE XR passes into breast milk. If you are breastfeeding, discuss the risks and benefits with your healthcare provider.
6. Alcohol Consumption:
   • Alcohol should be consumed cautiously while taking SITAPHAGE XR, as it can increase the risk of lactic acidosis and may alter blood sugar levels.

Dosage:

• Adults (usually once daily): The usual starting dose is 50 mg of Sitagliptin and 1000 mg of Metformin once a day, taken with the evening meal to help minimize gastrointestinal side effects.
• The dose may be adjusted by your doctor depending on your blood sugar levels and tolerance to the medication.
• Renal Impairment: Dosage adjustments may be necessary in individuals with kidney problems. Your healthcare provider will assess your kidney function and adjust the dosage as needed.

Important Note: Always follow the dosage instructions provided by your doctor or pharmacist. Do not take more or less than prescribed, and do not stop taking the medication without consulting your healthcare provider.

FAQ:

1. What is the difference between SITAPHAGE XR and regular Sitagliptin or Metformin?
   • SITAPHAGE XR is an extended-release formulation, meaning the medication is released slowly over time, providing more stable blood sugar control throughout the day. Regular Sitagliptin and Metformin tablets are typically taken multiple times a day.
2. Can I take SITAPHAGE XR with other diabetes medications?
   • Yes, SITAPHAGE XR can be used alongside other antidiabetic medications, such as insulin or sulfonylureas, for better blood sugar control. However, it is essential to monitor for signs of hypoglycemia (low blood sugar), especially if combined with insulin or other medications that can lower blood sugar.
3. Can I skip a dose of SITAPHAGE XR?
   • If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double your dose to make up for a missed one.
4. What should I do if I experience side effects?
   • Mild side effects, like gastrointestinal discomfort, may resolve on their own over time. However, if you experience more serious side effects, such as muscle pain, difficulty breathing, or yellowing of the skin (which could indicate lactic acidosis), seek medical help immediately.
5. Can SITAPHAGE XR help me lose weight?
   • Metformin, one of the active ingredients, has been associated with modest weight loss or weight neutrality in some people, which can be beneficial for individuals with Type 2 diabetes who are overweight. However, it is not a weight-loss drug.
6. How long will it take for SITAPHAGE XR to start working?
   • Most patients begin to see improvements in their blood sugar levels within a few days to a few weeks of starting SITAPHAGE XR. Full benefits are usually seen after consistent use over a longer period.