Azathioprine damps down an overactive immune system. It is used in autoimmune conditions and after transplant, and it works slowly, often taking two to three months before the benefit is clear.

What Azathioprine Is Used For

Rheumatoid arthritis and lupus
Inflammatory bowel disease
Preventing rejection after organ transplant
Some severe skin and neurological conditions

Common Side Effects

Nausea and loss of appetite
Low blood counts
Increased susceptibility to infection
Abnormal liver tests

Precautions

Regular blood tests for blood count and liver function are essential and are not optional. Report fever, sore throat, mouth ulcers or unexplained bruising, as these can signal a drop in blood cells. It must never be combined with allopurinol without a dose adjustment, as the combination is dangerous. Use sun protection, avoid live vaccines, and discuss any pregnancy plans with your specialist.

This page is general information only. It is not a substitute for advice from your doctor or pharmacist, and it does not include dosage. Always follow the directions given to you and read the leaflet inside the pack.