Methylestradiol is a synthetic oestrogen, a laboratory modified form of the natural female hormone estradiol. Synthetic oestrogens are used where oestrogen levels need replacing or where the menstrual cycle needs controlling, and they are almost always combined with a progestogen.

What Synthetic Oestrogens Are Used For

Hormone replacement for menopausal symptoms
Combined hormonal contraception
Irregular or absent periods caused by low oestrogen
Certain hormone related conditions, on specialist advice

Common Side Effects

Breast tenderness
Nausea
Headache
Fluid retention and breakthrough bleeding

Precautions

Oestrogens raise the risk of blood clots, and that risk is higher with smoking, obesity, migraine with aura, or a personal or family history of clots, so a proper assessment comes before a prescription. Report calf pain or swelling, chest pain, breathlessness, severe headache or sudden visual change immediately. They must not be used in pregnancy or with certain cancers, and they need review at least once a year.

This page is general information only. It is not a substitute for advice from your doctor or pharmacist, and it does not include dosage. Always follow the directions given to you and read the leaflet inside the pack.