Hydroxyurea slows the production of blood cells in the bone marrow. In sickle cell disease it also raises the level of fetal haemoglobin, which makes red cells less likely to sickle, reducing painful crises and hospital admissions.

What Hydroxyurea Is Used For

Sickle cell disease, to reduce painful crises
Chronic myeloid leukaemia and other myeloproliferative conditions
Thalassaemia, in selected patients
Certain other cancers, as decided by a specialist

Common Side Effects

Low blood counts
Nausea and mouth ulcers
Darkening of the skin and nails
Leg ulcers with long term use

Precautions

Regular blood counts are essential and the dose is adjusted to them. Report fever, sore throat, unusual bruising or bleeding straight away. Handle the capsules carefully and wash your hands afterwards. It can harm an unborn baby, so effective contraception is needed by both men and women during treatment and for a period after.

This page is general information only. It is not a substitute for advice from your doctor or pharmacist, and it does not include dosage. Always follow the directions given to you and read the leaflet inside the pack.