Methoxsalen makes skin far more sensitive to ultraviolet light. Given as a tablet or applied topically before controlled UVA exposure, that combination, known as PUVA, is used for vitiligo and psoriasis.

What Methoxsalen Is Used For

Vitiligo, to encourage repigmentation
Severe psoriasis not responding to other treatment
Some other skin conditions treated with light therapy

Common Side Effects

Redness and burning of treated skin
Nausea with the tablets
Itching and dryness
Increased risk of skin ageing and skin cancer with long term use

Precautions

Light exposure must be measured and supervised in a clinic, because ordinary sunlight after taking it can cause severe burns. Protective eyewear is worn for the day of treatment, since the eyes are also sensitised and cataracts are a long term risk. Avoid sun exposure for the rest of the treatment day and report any blistering.

This page is general information only. It is not a substitute for advice from your doctor or pharmacist, and it does not include dosage. Always follow the directions given to you and read the leaflet inside the pack.