Glucovance 5/500mg Tablet

Glucovance 5/500mg Tablet is a combination medication comprising two active ingredients: metformin and glibenclamide. It is primarily prescribed for managing type 2 diabetes mellitus to enhance glycemic control. Metformin belongs to the biguanide class of medications, while glibenclamide is a sulfonylurea. Together, they work synergistically to lower blood glucose levels through different mechanisms of action.

Ingredients:

1. Metformin: Metformin works by decreasing hepatic glucose production, reducing intestinal glucose absorption, and enhancing insulin sensitivity in peripheral tissues. Additionally, it improves glucose uptake and utilization by skeletal muscles.
2. Glibenclamide (Glyburide): Glibenclamide stimulates insulin secretion from pancreatic beta cells, leading to increased insulin levels in the bloodstream. It also enhances tissue sensitivity to insulin, facilitating improved glucose uptake by cells.

Uses:

Glucovance 5/500mg Tablet is prescribed for the following purposes:

• Management of type 2 diabetes mellitus: Glucovance helps lower blood glucose levels in individuals with type 2 diabetes by enhancing insulin action and secretion, thereby reducing hyperglycemia.
• Glycemic control: The combination of metformin and glibenclamide provides comprehensive glycemic control by targeting various pathways involved in glucose metabolism.

Side Effects:

While Glucovance 5/500mg Tablet is generally well-tolerated, some individuals may experience side effects, including:

• Gastrointestinal discomfort (nausea, vomiting, diarrhea, abdominal pain)
• Hypoglycemia (low blood sugar levels)
• Weight gain
• Headache
• Dizziness or lightheadedness
• Skin reactions (rash, itching)
• Metallic taste in the mouth

If you experience any severe or persistent side effects, inform your healthcare provider promptly.

Precautions:

• Inform your healthcare provider about any pre-existing medical conditions, allergies, or medications you are currently taking before starting Glucovance 5/500mg Tablet.
• Monitor blood glucose levels regularly while taking Glucovance to ensure optimal glycemic control and prevent hypoglycemia.
• Follow a balanced diet and exercise regimen as recommended by your doctor to complement the effects of Glucovance on blood sugar levels.

When Not to Use:

Glucovance 5/500mg Tablet should not be used in individuals with:

• Known hypersensitivity or allergy to metformin, glibenclamide, or any components of the tablet
• Type 1 diabetes mellitus
• Diabetic ketoacidosis
• Severe renal impairment or kidney dysfunction
• Severe hepatic impairment or liver disease
• History of lactic acidosis or diabetic coma

FAQ:

1. How should Glucovance 5/500mg Tablet be taken? Take Glucovance 5/500mg Tablet orally, with meals, as directed by your healthcare provider. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet unless instructed otherwise.
2. Can Glucovance 5/500mg Tablet cause hypoglycemia? Yes, Glucovance 5/500mg Tablet can cause hypoglycemia, especially when used in combination with other antidiabetic medications or insulin. Monitor blood glucose levels regularly and be aware of signs and symptoms of hypoglycemia, such as sweating, tremors, palpitations, and confusion.
3. Is it safe to drink alcohol while taking Glucovance 5/500mg Tablet? Alcohol consumption may potentiate the risk of hypoglycemia when taking Glucovance. Limit alcohol intake and avoid drinking alcohol on an empty stomach. Consult your healthcare provider for personalized recommendations regarding alcohol use while taking Glucovance.
4. Can Glucovance 5/500mg Tablet be used during pregnancy or breastfeeding? The safety of Glucovance 5/500mg Tablet during pregnancy or breastfeeding has not been established. Consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
5. What should I do if I miss a dose of Glucovance 5/500mg Tablet? If you miss a dose of Glucovance 5/500mg Tablet, take it as soon as you remember, with food. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.