Tmdl Plus 37.5/325mg Tablet

TMDL Plus 37.5/325mg Tablet is a combination medication containing two active ingredients: tramadol & paracetamol. Tramadol is an opioid pain reliever, while paracetamol is a mild analgesic and antipyretic agent. This combination is commonly prescribed for the management of moderate to severe pain.

Active Ingredients:

• Tramadol: Tramadol is an opioid analgesic that works by binding to mu-opioid receptors in the central nervous system, inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine. This action helps modulate pain perception and provides pain relief.
• Paracetamol: Paracetamol, also known as acetaminophen, is a non-opioid analgesic and antipyretic agent. It works by inhibiting the synthesis of prostaglandins in the central nervous system, which helps reduce pain and fever.

Uses:

TMDL Plus 37.5/325mg Tablet is indicated for the management of moderate to severe pain conditions, including:

1. Postoperative pain
2. Musculoskeletal pain
3. Dental pain
4. Neuralgia
5. Cancer pain

Mechanism of Action:

• Tramadol acts centrally by binding to mu-opioid receptors and inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine. This dual mechanism of action provides analgesic effects.
• Paracetamol works by inhibiting the synthesis of prostaglandins in the central nervous system, which reduces pain and fever.

Administration:

TMDL Plus 37.5/325mg Tablet is usually taken orally with or without food, as directed by a healthcare professional. The dosage regimen should be individualized based on the severity of pain and the patient’s response. It is important not to exceed the recommended dosage to avoid adverse effects.

Side Effects:

Common side effects of TMDL Plus 37.5/325mg Tablet may include:

• Nausea
• Dizziness
• Drowsiness
• Constipation
• Dry mouth
• Headache
• Sweating
• Fatigue

Precautions:

• TMDL Plus 37.5/325mg Tablet should be used with caution in patients with a history of opioid dependence, substance abuse, or respiratory depression.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of liver toxicity and central nervous system depression.
• Long-term use of tramadol may lead to physical dependence and withdrawal symptoms upon discontinuation.

Contraindications:

• TMDL Plus 37.5/325mg Tablet is contraindicated in patients with severe respiratory depression, acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic drugs.
• It should not be used in patients with severe hepatic impairment or acute liver disease.