Amitriptyline is a tricyclic antidepressant, though today it is prescribed more often at lower doses for nerve pain, migraine prevention and sleep than for depression itself. It changes how pain signals are processed rather than acting as a painkiller.

What Amitriptyline Is Used For

Nerve pain, including diabetic neuropathy and sciatica
Preventing migraine and tension headache
Fibromyalgia and chronic pain conditions
Depression, at higher doses
Bedwetting in children, on specialist advice

Common Side Effects

Drowsiness, which is why it is usually taken at night
Dry mouth and constipation
Blurred vision
Weight gain and dizziness on standing

Precautions

Benefit for pain builds over two to six weeks, so it needs a fair trial. Do not stop it suddenly after regular use. It is unsuitable soon after a heart attack and in some rhythm disorders, and older adults are more prone to falls and confusion with it. Avoid alcohol, and keep it out of reach of children, as overdose is dangerous.

This page is general information only. It is not a substitute for advice from your doctor or pharmacist, and it does not include dosage. Always follow the directions given to you and read the leaflet inside the pack.