DELTACORTRIL EC TABLET

DELTACORTRIL EC TABLET contains the active ingredient prednisolone, which is a synthetic corticosteroid. It is formulated as an enteric-coated tablet, designed to release the medication in the small intestine rather than the stomach. Prednisolone belongs to the class of medications known as glucocorticoids and possesses anti-inflammatory, immunosuppressive, and anti-allergic properties.

Active Ingredient:

• Prednisolone: A synthetic glucocorticoid that acts as an anti-inflammatory and immunosuppressant agent by inhibiting the production of inflammatory mediators and suppressing the immune response.

Mechanism of Action:

Prednisolone exerts its therapeutic effects by binding to glucocorticoid receptors in target cells, leading to the activation or suppression of specific genes involved in inflammatory and immune responses. It reduces inflammation by inhibiting the production of inflammatory cytokines, prostaglandins, and leukotrienes. Additionally, prednisolone suppresses the immune system by inhibiting the function of immune cells such as lymphocytes and macrophages.

Uses:

DELTACORTRIL EC tablet is indicated for the treatment of various inflammatory and autoimmune conditions, including:

• Rheumatoid arthritis
• Systemic lupus erythematosus (SLE)
• Asthma
• Allergic reactions
• Dermatological disorders (e.g., eczema, psoriasis)
• Inflammatory bowel disease (e.g., ulcerative colitis, Crohn’s disease)
• Autoimmune hepatitis
• Nephrotic syndrome
• Certain types of cancer (as part of combination therapy)

Dosage and Administration:

The dosage of DELTACORTRIL EC tablet varies depending on the condition being treated, the severity of symptoms, and the patient’s response to treatment. It is typically taken orally with water, preferably with food to minimize gastrointestinal irritation. The enteric-coated formulation is designed to be swallowed whole and should not be chewed or crushed.

Side Effects:

Common side effects of prednisolone therapy may include:

• Increased appetite
• Weight gain
• Fluid retention
• Elevated blood pressure
• Mood changes (e.g., irritability, anxiety)
• Insomnia
• Gastrointestinal disturbances (e.g., indigestion, nausea)
• Increased susceptibility to infections
• Glucose intolerance
• Osteoporosis (with long-term use)

Precautions:

• Patients taking DELTACORTRIL EC tablets should be monitored regularly for signs of adrenal suppression, including fatigue, weakness, and hypotension.
• Long-term use of prednisolone may increase the risk of osteoporosis, especially in postmenopausal women and elderly patients.
• Abrupt discontinuation of prednisolone therapy should be avoided to prevent adrenal insufficiency. Dosage tapering may be necessary under the guidance of a healthcare professional.
• Prednisolone may interact with other medications, so patients should inform their healthcare provider about all the drugs they are taking.
• Patients should be advised to avoid live vaccines while taking prednisolone due to the risk of vaccine failure.

Conclusion:

DELTACORTRIL EC tablet containing prednisolone is a widely used corticosteroid medication for the treatment of various inflammatory and autoimmune conditions. It is formulated as an enteric-coated tablet to minimize gastrointestinal irritation and ensure optimal drug absorption in the small intestine.

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