Duvel Plus 50/500mg Tablet

Duvel Plus 50/500mg Tablet is a combination medication designed for the management of type 2 diabetes mellitus in adults. It combines two active ingredients, sitagliptin and metformin, in one tablet. Sitagliptin belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which work by increasing the levels of incretin hormones, enhancing insulin release in response to meals and decreasing the amount of sugar produced by the liver. Metformin, on the other hand, is a biguanide that helps lower glucose production in the liver, reduces glucose absorption in the intestines, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. This dual action makes Duvel Plus effective in controlling high blood sugar levels in people with type 2 diabetes.

Uses:

• To improve blood sugar control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.
• Suitable for patients not adequately controlled on metformin alone or those currently treated with the combination of sitagliptin and metformin in separate tablets.

Side Effects:

Common side effects may include:

• Nausea, diarrhea, abdominal discomfort (often associated with metformin).
• Headaches.
• Nasopharyngitis (cold-like symptoms).
• Hypoglycemia, particularly when used in conjunction with other diabetes medications.

Less common but more severe side effects include:

• Lactic acidosis (a rare but serious condition related to metformin).
• Pancreatitis.
• Severe joint pain.
• Skin reactions.

Precautions:

• Not recommended for use in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
• Requires careful use in patients with renal impairment; kidney function should be assessed before starting therapy and periodically thereafter.
• Should be temporarily discontinued in patients undergoing radiologic studies involving intravenous contrast agents.
• Patients should avoid excessive alcohol intake while on this medication to reduce the risk of lactic acidosis.

When Not to Use:

• In individuals with hypersensitivity to sitagliptin, metformin, or any component of the product.
• Patients with severe renal impairment, acute or chronic metabolic acidosis, including diabetic ketoacidosis.

FAQ:

1. Can Duvel Plus be taken on an empty stomach?
   • To reduce gastrointestinal side effects, it is recommended to take Duvel Plus with meals.
2. What should I do if I miss a dose?
   • If you miss a dose of Duvel Plus, take it as soon as you remember unless it is close to the time of your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
3. Can I stop taking Duvel Plus if my blood sugar levels improve?
   • You should continue taking Duvel Plus as prescribed by your healthcare provider. Do not stop or alter your medication without consulting them, even if your blood sugar levels have improved.
4. How does Duvel Plus affect weight?
   • The effects of Duvel Plus on weight can vary. Metformin is often associated with weight loss or weight neutrality, whereas sitagliptin has a neutral effect on weight. The overall impact on weight will depend on the individual and their lifestyle.
5. Can Duvel Plus be used in combination with insulin?
   • Yes, Duvel Plus can be used in combination with insulin when necessary. However, this should be done under strict medical supervision to avoid the risk of hypoglycemia.