Itaglip Plus 50/500mg Tablet

Itaglip Plus 50/500mg Tablet is a combination medication containing Sitagliptin and Metformin. Sitagliptin is an oral antidiabetic agent that helps control blood sugar levels by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), thereby increasing the levels of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Metformin is a biguanide antidiabetic medication that works by decreasing glucose production in the liver and improving insulin sensitivity in the body.

Ingredients:

• Sitagliptin: Sitagliptin is a DPP-4 inhibitor that enhances the action of incretin hormones, leading to increased insulin secretion and decreased glucagon secretion, resulting in improved glycemic control.
• Metformin: Metformin works by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity, thereby lowering blood sugar levels.

Uses:

Itaglip Plus 50/500mg Tablet is indicated for the management of type 2 diabetes mellitus to improve glycemic control in patients whose blood sugar levels are inadequately controlled with diet and exercise alone. It helps lower blood sugar levels by increasing insulin secretion and reducing hepatic glucose production.

Side Effects:

1. Gastrointestinal Effects: Common side effects may include nausea, vomiting, diarrhea, abdominal discomfort, and metallic taste.
2. Hypoglycemia: Taking Itaglip Plus 50/500mg Tablet may increase the risk of hypoglycemia, particularly when used in combination with other antidiabetic medications.
3. Lactic Acidosis: Rare but serious side effects of Metformin may include lactic acidosis, a potentially life-threatening condition characterized by elevated blood lactate levels and metabolic acidosis.
4. Hypersensitivity Reactions: Allergic reactions to Sitagliptin or Metformin may occur, manifesting as rash, itching, swelling, or difficulty breathing.

Precautions:

1. Renal Function: Itaglip Plus 50/500mg Tablet should be used with caution in patients with renal impairment, as Metformin is excreted by the kidneys. Dosage adjustments may be necessary to prevent the accumulation of Metformin and reduce the risk of lactic acidosis.
2. Hepatic Function: Use with caution in patients with hepatic impairment, as Metformin metabolism may be impaired, leading to an increased risk of lactic acidosis.
3. Hypoglycemia: Monitor blood glucose levels regularly, especially when starting or adjusting the dosage of Itaglip Plus 50/500mg Tablet, to minimize the risk of hypoglycemia.
4. Elderly Patients: Elderly patients may be more susceptible to the side effects of Itaglip Plus 50/500mg Tablet, particularly gastrointestinal effects and lactic acidosis. Close monitoring is recommended in this population.

When Not to Use:

Itaglip Plus 50/500mg Tablet is contraindicated in patients with:

• Hypersensitivity to Sitagliptin, Metformin, or any component of the tablet.
• Severe renal impairment (eGFR <30 mL/min/1.73 m²) or end-stage renal disease.
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.

FAQ:

1. How should Itaglip Plus 50/500mg Tablet be taken?
   • Itaglip Plus 50/500mg Tablet is usually taken orally with meals to reduce gastrointestinal side effects. The dosage may vary depending on the patient’s blood sugar levels and renal function.
2. What should I do if I miss a dose of Itaglip Plus 50/500mg Tablet?
   • If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. Patients should not double the dose to make up for a missed dose and should continue with the regular dosing schedule.
3. Can Itaglip Plus 50/500mg Tablet be used in children?
   • The safety and efficacy of Itaglip Plus 50/500mg Tablet in children have not been established. It is generally not recommended for use in pediatric patients.
4. Is Itaglip Plus 50/500mg Tablet safe during pregnancy and breastfeeding?
   • Itaglip Plus 50/500mg Tablet should be used during pregnancy only if the potential benefits outweigh the risks to the fetus. It is not recommended for use while breastfeeding, as it is not known whether Sitagliptin or Metformin excreted in breast milk.
5. Can Itaglip Plus 50/500mg Tablet cause weight gain?
   • Itaglip Plus 50/500mg Tablet is not typically associated with weight gain. In fact, Metformin may help with weight loss in some individuals by improving insulin sensitivity and reducing appetite. However, individual responses may vary.