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Simulect 20mg Tablet
NOVARTIS PHARMA (PAKISTAN)LTD

Simulect 20mg Tablet

₨ 113,697

In stock
FormulaBasiliximab (20mg)
Pack size1's
FormTablet
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Delivery in 2 to 3 working daysTo cities across Pakistan, delivery from ₨ 300
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About this product

Overview

Simulect 20mg Tablet is a medication that contains the active ingredient basiliximab. It is available in injectable form and is used as an immunosuppressant agent. Basiliximab is a monoclonal antibody that binds to the alpha chain of the interleukin-2 (IL-2) receptor (CD25), thereby inhibiting IL-2-mediated activation of T lymphocytes. This action helps prevent acute rejection of transplanted organs, particularly in kidney transplant recipients.

Active Ingredient

  • Basiliximab: Basiliximab is a chimeric monoclonal antibody that selectively binds to the IL-2 receptor alpha chain (CD25) expressed on activated T lymphocytes. By blocking IL-2 binding to its receptor, basiliximab inhibits T cell activation, proliferation, and differentiation, which are critical processes involved in allograft rejection.

Mechanism of Action

Simulect 20mg Tablet works by binding to the alpha chain of the IL-2 receptor (CD25) on the surface of activated T lymphocytes. By blocking IL-2-mediated signaling, basiliximab inhibits T cell activation and proliferation, thereby suppressing the immune response against the transplanted organ. This helps prevent acute rejection and improves transplant outcomes.

Uses

Simulect 20mg Tablet is indicated for the prophylaxis of acute organ rejection in patients receiving renal transplantation. It is typically used in combination with other immunosuppressive agents, such as corticosteroids and calcineurin inhibitors (e.g., cyclosporine or tacrolimus).

Dosage and Administration

The recommended dosage of Simulect 20mg Tablet is based on body weight and is administered as an intravenous infusion over approximately 20 to 30 minutes. The initial dose is typically given within 2 hours before transplantation surgery, followed by a second dose 4 days later.

Side Effects

Common side effects of Simulect 20mg Tablet may include:

  • Fever
  • Hypertension (high blood pressure)
  • Peripheral edema
  • Headache
  • Nausea
  • Diarrhea
  • Infection
  • Leukopenia (low white blood cell count)

Precautions

  • Simulect should be used with caution in patients with a history of hypersensitivity reactions to basiliximab or other murine protein-containing products.
  • Patients should be monitored for signs of hypersensitivity reactions, infections, and other adverse effects during treatment with Simulect.
  • Concomitant use of live vaccines should be avoided during basiliximab therapy due to the risk of diminished immune response.

Simulect 20mg Tablet containing basiliximab is an effective immunosuppressant medication used for the prophylaxis of acute organ rejection in kidney transplant recipients. By targeting the IL-2 receptor on activated T lymphocytes, basiliximab helps prevent allograft rejection and improves the success of kidney transplantation.

This information is for general awareness only. It does not replace advice from your doctor or pharmacist. Always read the leaflet and follow the directions you were given.

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