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Title: Pioglitazone: Uses, Side Effects, and Precautions

What is Pioglitazone?

Pioglitazone is an oral medication used to treat type 2 diabetes. It belongs to a class of drugs called thiazolidinediones, which work by increasing the sensitivity of cells to insulin, a hormone that regulates blood sugar levels in the body. Pioglitazone is sold under the brand name Actos.

How Does Pioglitazone Work?

Type 2 diabetes is characterized by high levels of sugar (glucose) in the blood. Insulin helps the body’s cells use glucose for energy. In people with type 2 diabetes, the cells become resistant to insulin, causing high levels of glucose to accumulate in the blood. Pioglitazone works by increasing the sensitivity of cells to insulin, allowing them to use glucose more effectively. This helps to lower blood sugar levels in people with type 2 diabetes.

Uses of Pioglitazone

Pioglitazone is used to treat type 2 diabetes in adults. It is typically used in combination with diet and exercise to lower blood sugar levels.

Side Effects of Pioglitazone

Like all medications, pioglitazone may cause side effects in some people. The most common side effects of pioglitazone are:

  • Headache
  • Upper respiratory tract infection
  • Sinus infection
  • Flu

Less common side effects of pioglitazone include:

  • Rash
  • Itching
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing

Serious side effects of pioglitazone, although rare, include:

  • Chest pain
  • Shortness of breath
  • Rapid heartbeat
  • Swelling of the hands, feet, ankles, or lower legs
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Changes in urine or stool color
  • Dark urine
  • Persistent stomach pain
  • Persistent nausea or vomiting

If you experience any of these serious side effects, stop taking pioglitazone and seek medical attention immediately.

Precautions and Warnings

Before taking pioglitazone, inform your healthcare provider if you have any of the following conditions:

  • Heart disease
  • High blood pressure
  • Kidney or liver disease
  • Asthma
  • A bleeding or blood clotting disorder
  • A history of stomach ulcers or gastrointestinal bleeding
  • A history of allergic reactions to thiazolidinediones

Pioglitazone may increase the risk of heart attack or stroke, especially in people who have a history of cardiovascular disease. It may also increase the risk of bladder cancer.

Pioglitazone may interfere with certain laboratory tests, such as urine glucose tests. If you are scheduled for any laboratory tests, inform your healthcare provider that you are taking pioglitazone.

Pioglitazone may cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how pioglitazone affects you.

Pioglitazone should not be used during pregnancy unless the potential benefits outweigh the potential risks. It is not known if pioglitazone is excreted in breast milk. Consult your healthcare provider before breastfeeding while taking pioglitazone.


Pioglitazone is a prescription medication used to treat type 2 diabetes in adults. It works by increasing the sensitivity of cells to insulin, allowing

Medicines Contains Pioglitazone

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