Sitagen-Mxr 100/1000mg Tablet

Sitagen-Mxr 100/1000mg Tablet is a combination medication containing two active ingredients: Sitagliptin & Metformin. Sitagliptin belongs to the class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors, while Metformin is a biguanide antidiabetic agent. This combination is used in the management of type 2 diabetes mellitus to help control blood sugar levels. Sitagliptin works by increasing the release of insulin from the pancreas and decreasing the production of glucagon, a hormone that raises blood sugar levels. Metformin helps to reduce glucose production in the liver and improve insulin sensitivity in peripheral tissues.

Uses:

1. Type 2 Diabetes Mellitus: Sitagen-Mxr 100/1000mg Tablet is indicated for the treatment of type 2 diabetes mellitus in adults. It helps to improve glycemic control by lowering blood sugar levels through different mechanisms of action. This medication is typically used as an adjunct to diet and exercise in patients whose blood sugar levels are inadequately controlled with either Sitagliptin or Metformin alone.

Side Effects:

While Sitagen-Mxr 100/1000mg Tablet is generally well-tolerated, it may cause side effects in some individuals. Common side effects associated with Sitagliptin and Metformin combination therapy include:

• Gastrointestinal Disturbances: Common gastrointestinal side effects include nausea, diarrhea, and abdominal discomfort. These symptoms are usually mild and transient, but patients should inform their healthcare provider if they persist or worsen.
• Hypoglycemia: Low blood sugar levels (hypoglycemia) may occur, particularly when Sitagen-Mxr 100/1000mg Tablet is used in combination with other antidiabetic medications or insulin. Patients should be educated about the signs and symptoms of hypoglycemia and instructed on appropriate management.
• Hypersensitivity Reactions: Rarely, hypersensitivity reactions such as skin rash, itching, and swelling of the face, lips, or tongue may occur. Patients should seek immediate medical attention if they experience any signs of a severe allergic reaction.

Precautions:

• Renal Function: Sitagen-Mxr 100/1000mg Tablet should be used with caution in patients with impaired renal function, as Metformin is excreted by the kidneys. Renal function should be assessed before starting treatment and regularly thereafter.
• Hepatic Function: Patients with liver impairment should use Sitagen-Mxr 100/1000mg Tablet with caution, as Metformin is contraindicated in severe liver disease. Liver function tests should be monitored periodically.
• Heart Failure: Sitagliptin has been associated with an increased risk of heart failure, particularly in patients with a history of heart disease. Patients with heart failure should use this medication with caution and be closely monitored for signs and symptoms of worsening heart failure.