Sitagen-Mxr 50/1000mg Tablet is a combination medication containing two active ingredients: Sitagliptin & Metformin. Sitagliptin belongs to a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors, while Metformin is a biguanide antidiabetic agent. This combination is used in the management of type 2 diabetes mellitus to help control blood sugar levels. Sitagliptin works by increasing the levels of incretin hormones, which stimulate insulin release and inhibit glucagon secretion. Metformin helps to reduce glucose production in the liver and improve insulin sensitivity in peripheral tissues.

Uses:

Type 2 Diabetes Mellitus: Sitagen-Mxr 50/1000mg Tablet is indicated for the treatment of type 2 diabetes mellitus in adults. It helps to improve glycemic control by lowering blood sugar levels through different mechanisms of action. This medication is typically used as an adjunct to diet and exercise in patients whose blood sugar levels are inadequately controlled with either Sitagliptin or Metformin alone.

Side Effects:

While Sitagen-Mxr 50/1000mg Tablet is generally well-tolerated, it may cause side effects in some individuals. Common side effects associated with Sitagliptin and Metformin combination therapy include:

Gastrointestinal Disturbances: Common gastrointestinal side effects include nausea, diarrhea, and abdominal discomfort. These symptoms are usually mild and transient, but patients should inform their healthcare provider if they persist or worsen.
Hypoglycemia: Low blood sugar levels (hypoglycemia) may occur, particularly when Sitagen-Mxr 50/1000mg Tablet is used in combination with other antidiabetic medications or insulin. Patients should be educated about the signs and symptoms of hypoglycemia and instructed on appropriate management.
Headache: Headaches are a commonly reported side effect during treatment with Sitagen-Mxr 50/1000mg Tablet. Most headaches are mild and transient.

Precautions:

Renal Function: Sitagen-Mxr 50/1000mg Tablet should be used with caution in patients with impaired renal function, as Metformin is excreted by the kidneys. Renal function should be assessed before starting treatment and regularly thereafter.
Hepatic Function: Patients with liver impairment should use Sitagen-Mxr 50/1000mg Tablet with caution, as Metformin is contraindicated in severe liver disease. Liver function tests should be monitored periodically.
Hypotension: Sitagliptin may cause a decrease in blood pressure, particularly in patients with a history of hypotension or dehydration. Blood pressure should be monitored regularly during treatment.
Pancreatitis: Rare cases of pancreatitis have been reported with the use of Sitagliptin. Patients should be advised to seek medical attention if they experience persistent severe abdominal pain.