TRELAGET 100MG TABLETS

TRELAGET 100MG TABLETS  contain Trelagliptin, which is a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor). It is used in the management of Type 2 Diabetes Mellitus to help control blood glucose levels. Trelagliptin works by enhancing the body’s natural insulin response after eating, while also reducing the production of glucose by the liver.

As a once-weekly oral medication, Trelagliptin offers a convenient option for patients who need ongoing control of their blood sugar but may find daily medication regimens challenging. Trelagliptin is part of a class of drugs called gliptins, which are known for their effectiveness in controlling blood sugar with a lower risk of causing hypoglycemia (low blood sugar) compared to some other antidiabetic agents.

TRELAGET is typically prescribed in conjunction with diet and exercise, and sometimes other antidiabetic drugs, to improve blood sugar control in adults with Type 2 diabetes.

Uses:

TRELAGET 100MG is used primarily for the treatment of Type 2 Diabetes Mellitus in the following ways:

1. Blood Sugar Control:
   • TRELAGET helps lower blood sugar levels by improving the body’s natural ability to regulate glucose, especially after meals. It does this by inhibiting the DPP-4 enzyme, which prolongs the action of incretin hormones (GLP-1 and GIP) that stimulate insulin release and inhibit glucagon release.
2. Monotherapy or Combination Therapy:
   • TRELAGET can be used alone (monotherapy) or in combination with other diabetes medications, including metformin, sulfonylureas, or insulin, when blood sugar control is not adequately achieved by diet and exercise alone.
3. Long-Acting Option:
   • As a once-weekly tablet, TRELAGET offers the advantage of less frequent dosing, improving adherence to the treatment regimen, especially for patients who struggle with taking medications daily.

Mechanism of Action:

Trelagliptin inhibits the enzyme DPP-4, which breaks down incretin hormones. By preventing the breakdown of these hormones, Trelagliptin enhances their effects, including:

• Increasing insulin secretion from the pancreas in response to meals.
• Decreasing glucagon secretion, which reduces the liver’s production of glucose.

This combination helps reduce postprandial (after-meal) blood sugar spikes and improves overall blood sugar control.

Side Effects:

Like any medication, TRELAGET may cause side effects, although not everyone experiences them. Common side effects include:

• Gastrointestinal issues: These can include nausea, diarrhea, stomach discomfort, and constipation. These are typically mild and often resolve as your body adjusts to the medication.
• Headache: Some individuals may experience headaches while taking TRELAGET.
• Upper respiratory infections: Symptoms such as a sore throat, runny nose, or coughing can occur, similar to symptoms of a common cold.

Side Effects:

• Pancreatitis: Although rare, there have been reports of inflammation of the pancreas (pancreatitis) in patients taking DPP-4 inhibitors. Symptoms of pancreatitis include severe abdominal pain, nausea, and vomiting. If you experience these symptoms, seek medical help immediately.
• Allergic reactions: Some individuals may experience signs of an allergic reaction, such as skin rashes, itching, swelling (especially of the face, lips, or tongue), or trouble breathing.
• Severe joint pain: Some DPP-4 inhibitors have been linked to joint pain or inflammation. If you experience severe pain or discomfort in your joints, consult your healthcare provider.

Hypoglycemia: TRELAGET on its own does not commonly cause hypoglycemia, but the risk increases if it is taken with other medications that lower blood sugar, such as insulin or sulfonylureas. Symptoms of low blood sugar include shakiness, dizziness, sweating, and confusion.

Precautions:

1. Allergic Reactions:
   • If you have a history of allergies to DPP-4 inhibitors, consult your doctor before starting TRELAGET. Discontinue the medication and seek medical attention if you experience signs of an allergic reaction.
2. Pancreatic Issues:
   • TRELAGET should be used cautiously in patients with a history of pancreatitis or gallstones, as it may increase the risk of developing pancreatitis. Any signs of severe abdominal pain should be evaluated by a healthcare professional.
3. Kidney Function:
   • Trelagliptin is generally safe for individuals with mild to moderate kidney impairment, but caution is recommended in those with severe kidney dysfunction. Kidney function should be monitored during treatment.
4. Pregnancy and Breastfeeding:
   • Pregnancy: TRELAGET should only be used during pregnancy if the benefits outweigh the risks. It is classified as Category C (animal studies show risks to the fetus, but there are no well-controlled studies in humans).
   • Breastfeeding: It is not known whether Trelagliptin is excreted in human breast milk. If you are breastfeeding or plan to breastfeed, consult your doctor to determine if TRELAGET is appropriate for you.
5. Use in Children:
   • Trelagliptin is not recommended for use in children under 18 years old, as safety and efficacy have not been established in this population.

Dosage:

• Adults: The typical dose of TRELAGET 100MG is one tablet once a week. It can be taken with or without food.
• Renal Impairment: While Trelagliptin is generally safe for those with mild to moderate renal impairment, it should be used cautiously in patients with severe kidney disease. Your healthcare provider will monitor your kidney function during treatment.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once to make up for a missed dose.

FAQ:

1. How does TRELAGET work?
   • TRELAGET works by inhibiting the DPP-4 enzyme, which prolongs the effects of incretin hormones that help regulate blood sugar. This enhances insulin secretion and reduces glucose production by the liver.
2. Can I take TRELAGET with other diabetes medications?
   • Yes, TRELAGET can be used in combination with other diabetes medications like metformin, insulin, or sulfonylureas. However, if used together with insulin or sulfonylureas, there may be an increased risk of hypoglycemia (low blood sugar).
3. How should I take TRELAGET?
   • TRELAGET is taken once a week as a single tablet. It can be taken with or without food. Make sure to follow your healthcare provider’s instructions for the best results.
4. Can I miss a dose of TRELAGET?
   • If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once.
5. Does TRELAGET cause weight gain?
   • Trelagliptin is generally weight-neutral, meaning it typically does not cause significant weight gain or loss. However, it may help control blood sugar levels, which can indirectly support weight management when used alongside a healthy diet and exercise.
6. What should I do if I experience side effects?
   • If you experience common side effects like nausea or headache, they may improve over time. However, if you notice severe symptoms like abdominal pain, jaundice (yellowing of the skin or eyes), or an allergic reaction, stop taking TRELAGET and seek medical attention immediately.