Valsatril 24mg/26mg Tablet is a combination medication that contains two active ingredients, Sacubitril & Valsartan. This combination is often prescribed for the treatment of heart failure. Sacubitril belongs to the neprilysin inhibitor class, while Valsartan is an angiotensin II receptor blocker (ARB).
Valsatril is primarily indicated for the management of chronic heart failure in adult patients with reduced ejection fraction. It is prescribed when an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) alone may not provide sufficient heart failure management.
Mechanism of Action:
- Sacubitril: Inhibits neprilysin, an enzyme that breaks down beneficial peptides.
- Valsartan: Blocks the action of angiotensin II, a substance that narrows blood vessels and releases aldosterone, leading to increased blood pressure.
Dosage and Administration: The dosage of Valsatril is determined by the treating healthcare provider based on the patient’s condition and response to treatment. It is administered orally.
- Pregnancy and Breastfeeding: Consultation with a healthcare provider is essential for pregnant or breastfeeding individuals before using Valsatril.
- Renal Impairment: Caution is advised in patients with kidney problems, and dose adjustments may be necessary.
Common side effects may include dizziness, low blood pressure, and an increased level of potassium in the blood. Serious side effects are rare but may include kidney problems.
When Not to Use:
Valsatril should not be used in patients who are allergic to Sacubitril or Valsartan. It is also contraindicated in patients with a history of angioedema related to previous ACE inhibitor or ARB therapy.
Note: This information serves as a general overview and is not a substitute for professional medical advice. Patients should consult their healthcare provider for personalized guidance on Valsatril and its usage, considering individual health conditions and needs.