Orinase-Met 1.0/500mg Tablet

Orinase-Met 1.0/500mg Tablet is a combination medication containing two active ingredients: Glimepiride and Metformin. Glimepiride belongs to the sulfonylurea class of antidiabetic drugs, while Metformin is a biguanide antidiabetic agent. This combination is used for the management of type 2 diabetes mellitus to improve glycemic control by targeting different mechanisms of action.

Composition:

Each Orinase-Met 1.0/500mg Tablet contains:

• Glimepiride 1.0 mg
• Metformin Hydrochloride 500 mg

Uses:

1. Control of Blood Sugar Levels: Orinase-Met 1.0/500mg Tablet is indicated for the treatment of type 2 diabetes mellitus to lower and control blood sugar levels.
2. Adjunct to Diet and Exercise: It is used as an adjunct to diet and exercise to achieve optimal glycemic control in patients with diabetes who have not achieved adequate blood sugar control with lifestyle modifications alone.

Mechanism of Action:

1. Glimepiride: Stimulates the release of insulin from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues, leading to increased glucose uptake and utilization.
2. Metformin: Decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues, thereby lowering blood sugar levels.

Dosage and Administration:

• Orinase-Met 1.0/500mg Tablet should be taken orally with meals to reduce gastrointestinal side effects.
• The dosage may vary depending on individual patient factors, including the severity of diabetes, renal function, and response to treatment.
• Your doctor will determine the appropriate dosage regimen for you.

Side Effects:

Common side effects associated with Orinase-Met 1.0/500mg Tablet may include:

1. Nausea or vomiting
2. Diarrhea
3. Abdominal discomfort or pain
4. Hypoglycemia (low blood sugar)
5. Headache
6. Dizziness
7. Metallic taste in the mouth

Inform your doctor if any side effects persist or become bothersome.

Precautions:

Before using Orinase-Met 1.0/500mg Tablet, consider the following precautions:

1. Monitor Blood Sugar Levels: Regular monitoring of blood glucose levels is essential to assess the effectiveness of treatment and adjust the dosage of Orinase-Met accordingly to minimize the risk of hypoglycemia or hyperglycemia.
2. Avoid Alcohol: Limit or avoid alcohol consumption while taking Orinase-Met, as it may potentiate the risk of hypoglycemia.
3. Use in Pregnancy and Lactation: Use Orinase-Met with caution during pregnancy and breastfeeding, as safety data in these populations are limited. Consult your doctor for personalized recommendations.
4. Risk of Hypoglycemia: Be aware of the signs and symptoms of hypoglycemia (such as sweating, tremors, palpitations, confusion) and take appropriate measures to treat low blood sugar episodes promptly, such as consuming glucose tablets or sugary snacks.
5. Interactions with Other Medications: Inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, as they may interact with Orinase-Met and affect blood sugar control.

FAQs:

1. How does Orinase-Met 1.0/500mg Tablet work to lower blood sugar levels? The combination of Glimepiride and Metformin targets different mechanisms of action to improve glycemic control. Glimepiride stimulates insulin release, while Metformin reduces hepatic glucose production and enhances insulin sensitivity.
2. What should I do if I miss a dose of Orinase-Met 1.0/500mg Tablet? If you miss a dose of Orinase-Met, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
3. Can Orinase-Met 1.0/500mg Tablet be used alone for the treatment of diabetes? Orinase-Met is usually used as part of a comprehensive treatment plan for type 2 diabetes mellitus. Your doctor may adjust your treatment regimen based on your individual needs and response to therapy.
4. Can Orinase-Met 1.0/500mg Tablet cause weight gain? Weight gain is a potential side effect of some antidiabetic medications, including Orinase-Met. Monitor your weight regularly and discuss any significant changes with your doctor.
5. Can Orinase-Met 1.0/500mg Tablet be used in elderly patients? Orinase-Met can be used in elderly patients with type 2 diabetes mellitus; however, caution should be exercised due to the increased risk of hypoglycemia and other adverse effects. Dosage adjustments may be necessary based on individual patient factors and renal function.