Itaglip Plus 50/1000mg Tablet

Itaglip Plus 50/1000mg Tablet is a combination medication containing Sitagliptin (50mg) and Metformin (1000mg) as its active ingredients. It is used for the management of type 2 diabetes mellitus to help control blood sugar levels.

Ingredients:

• Sitagliptin (50mg): Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the levels of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion and inhibit glucagon secretion, thereby reducing blood sugar levels.
• Metformin (1000mg): Metformin is a biguanide antidiabetic medication that works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues, leading to reduced blood sugar levels.

Uses:

Itaglip Plus 50/1000mg Tablet is indicated for the treatment of type 2 diabetes mellitus. It helps lower blood sugar levels by increasing insulin secretion, reducing glucagon secretion, and improving insulin sensitivity. It is usually prescribed in combination with diet and exercise.

Side Effects:

1. Hypoglycemia: Taking Itaglip Plus 50/1000mg Tablet may increase the risk of hypoglycemia, particularly when used in combination with other antidiabetic medications.
2. Gastrointestinal Effects: Common side effects may include gastrointestinal upset such as nausea, diarrhea, or abdominal discomfort.
3. Upper Respiratory Tract Infection: Some individuals may experience upper respiratory tract infections such as cold or flu-like symptoms.
4. Lactic Acidosis: Metformin, one of the components of Itaglip Plus 50/1000mg Tablet, may rarely cause lactic acidosis, a serious condition characterized by the buildup of lactic acid in the blood.

Precautions:

1. Renal Impairment: Use with caution in patients with renal impairment, as Metformin is excreted by the kidneys and may accumulate in patients with impaired renal function, increasing the risk of lactic acidosis.
2. Hypersensitivity Reactions: Discontinue Itaglip Plus 50/1000mg Tablet and seek medical attention if signs of hypersensitivity reactions, such as rash, itching, swelling, or difficulty breathing, occur.
3. Hepatic Impairment: Use with caution in patients with hepatic impairment, as both Sitagliptin and Metformin may affect liver function, and data on their use in patients with severe hepatic impairment are limited.

When Not to Use:

Itaglip Plus 50/1000mg Tablet is contraindicated in patients with:

• Known hypersensitivity to Sitagliptin, Metformin, or any component of the tablet.
• Severe renal impairment (eGFR < 30 mL/min/1.73 m²) or end-stage renal disease requiring dialysis.
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.

FAQ:

1. How should Itaglip Plus 50/1000mg Tablet be taken?
   • Itaglip Plus 50/1000mg Tablet is usually taken orally with meals to reduce gastrointestinal side effects. The dosage and frequency of administration are determined by a healthcare professional based on the patient’s blood sugar levels and renal function.
2. Can Itaglip Plus 50/1000mg Tablet be used alone or in combination with other antidiabetic medications?
   • Itaglip Plus 50/1000mg Tablet is a combination medication and is typically used alone or in combination with other antidiabetic medications such as insulin or sulfonylureas, depending on the patient’s blood sugar control and treatment goals.
3. Is Itaglip Plus 50/1000mg Tablet safe during pregnancy and breastfeeding?
   • The safety of Itaglip Plus 50/1000mg Tablet during pregnancy and breastfeeding has not been established. It should be used during pregnancy or breastfeeding only if the potential benefits outweigh the risks to the mother and fetus or infant.
4. What should I do if I miss a dose of Itaglip Plus 50/1000mg Tablet?
   • If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. Patients should not double the dose to make up for a missed dose and should continue with the regular dosing schedule.
5. Can Itaglip Plus 50/1000mg Tablet cause weight gain?
   • Weight gain is not a common side effect of Itaglip Plus 50/1000mg Tablet. However, individual responses may vary, and patients should monitor their weight regularly while taking this medication.