Onbrez 300mcg Tablet

Onbrez 300mcg Tablet contains the active ingredient indacaterol maleate and is available in tablet form. It is a medication used for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Indacaterol is a long-acting beta agonist (LABA) bronchodilator that helps relax and open the airways in the lungs, making it easier to breathe.

Active Ingredient:

• Indacaterol Maleate: Indacaterol is a selective long-acting beta-2 adrenergic agonist (LABA) that acts on beta-2 adrenergic receptors in the airway smooth muscle cells. By binding to these receptors, indacaterol activates intracellular signaling pathways that lead to relaxation of the smooth muscles surrounding the airways, resulting in bronchodilation and improved airflow.

Mechanism of Action:

Onbrez 300mcg Tablet works by stimulating beta-2 adrenergic receptors in the smooth muscle cells of the airways. Activation of these receptors leads to activation of adenylate cyclase, increased levels of cyclic adenosine monophosphate (cAMP), and subsequent relaxation of the bronchial smooth muscle. This results in bronchodilation, improved airflow, and relief of symptoms such as wheezing, shortness of breath, and coughing in patients with COPD.

Uses:

Onbrez 300mcg Tablet is indicated for:

1. Long-term maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema.
2. Reduction of COPD exacerbations and improvement of lung function in patients with moderate to severe COPD.
3. Symptomatic relief of dyspnea (shortness of breath), wheezing, and cough associated with COPD.

Dosage and Administration:

The recommended dosage of Onbrez 300mcg Tablet is one tablet (300mcg) taken orally once daily, preferably at the same time each day. The tablet should be swallowed whole with water and should not be chewed or crushed. The dosage may be adjusted based on individual patient response and tolerability.

Side Effects:

Common side effects associated with Onbrez 300mcg Tablet may include:

• Headache
• Dizziness
• Nausea
• Dry mouth
• Cough
• Sore throat
• Muscle cramps
• Tremor
• Palpitations

Precautions:

• Onbrez 300mcg Tablet should be used with caution in patients with cardiovascular disorders, including hypertension, coronary artery disease, and arrhythmias.
• Patients should be monitored closely for signs of worsening COPD symptoms, including increased dyspnea and decreased exercise tolerance, especially during initiation of therapy.
• Onbrez may interact with other medications, so patients should inform their healthcare provider about all prescription and over-the-counter drugs they are taking.

Conclusion:

Onbrez 300mcg Tablet containing indacaterol maleate is an effective long-acting bronchodilator used for the maintenance treatment of COPD. By selectively stimulating beta-2 adrenergic receptors in the airways, indacaterol helps relax bronchial smooth muscles, improve airflow, and relieve symptoms of COPD, thereby enhancing the quality of life for affected patients.