Glucovance 250/1.25mg Tablet

Glucovance 250/1.25mg Tablet combines two active ingredients: metformin & glibenclamide. Metformin belongs to the biguanide class of medications, while glibenclamide is a sulfonylurea. This combination medication is primarily prescribed for the management of type 2 diabetes mellitus to improve glycemic control. Metformin works by reducing hepatic glucose production, enhancing insulin sensitivity in peripheral tissues, and decreasing intestinal glucose absorption, thereby lowering blood glucose levels. Glibenclamide stimulates insulin release from pancreatic beta cells, thereby further reducing blood sugar levels.

Ingredients:

• Metformin: Metformin acts primarily by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues. Additionally, it enhances glucose uptake and utilization by skeletal muscles.
• Glibenclamide: Glibenclamide stimulates insulin release from pancreatic beta cells, leading to a decrease in blood glucose levels.

Uses:

Glucovance 250/1.25mg Tablet is prescribed for the following purposes:

• Management of type 2 diabetes mellitus: Glucovance helps lower blood glucose levels in individuals with type 2 diabetes by improving insulin action, reducing insulin resistance, and stimulating insulin release.
• Glycemic control: This combination medication is used as part of a comprehensive treatment regimen to achieve and maintain optimal blood sugar levels.

Side Effects:

While Glucovance 250/1.25mg Tablet is generally well-tolerated, some individuals may experience side effects, including:

• Gastrointestinal discomfort (nausea, vomiting, diarrhea, abdominal pain)
• Hypoglycemia (low blood sugar levels)
• Weight gain
• Allergic reactions (rash, itching, swelling)
• Elevated liver enzymes

If you experience any severe or persistent side effects, inform your healthcare provider promptly.

Precautions:

• Inform your healthcare provider about any pre-existing medical conditions, allergies, or medications you are currently taking before starting Glucovance 250/1.25mg Tablet.
• Monitor blood glucose levels regularly while taking Glucovance to ensure optimal glycemic control.
• Be cautious when using Glucovance in elderly patients or those with renal impairment, hepatic dysfunction, or other predisposing factors.

When Not to Use:

Glucovance 250/1.25mg Tablet should not be used in individuals with:

• Known hypersensitivity or allergy to metformin, glibenclamide, or any components of the tablet
• Type 1 diabetes mellitus
• Diabetic ketoacidosis
• Severe renal impairment or kidney dysfunction
• Severe hepatic impairment or liver disease
• Pregnancy or breastfeeding (unless otherwise directed by your healthcare provider)

FAQ:

1. How should Glucovance 250/1.25mg Tablet be taken? Take Glucovance 250/1.25mg Tablet orally, with meals, as directed by your healthcare provider. Swallow the tablet whole with a glass of water. Follow your doctor’s instructions carefully regarding dosage and administration.
2. Can Glucovance 250/1.25mg Tablet cause hypoglycemia? Hypoglycemia (low blood sugar) is a potential side effect of glibenclamide, one of the components of Glucovance. Monitor blood sugar levels regularly and be cautious to prevent hypoglycemic episodes. Symptoms of hypoglycemia include sweating, shaking, confusion, dizziness, and rapid heartbeat.
3. Is it safe to drink alcohol while taking Glucovance 250/1.25mg Tablet? Alcohol consumption may potentiate the risk of hypoglycemia when taking Glucovance. Limit alcohol intake and avoid excessive alcohol consumption while taking this medication.
4. Can Glucovance 250/1.25mg Tablet be used during pregnancy or breastfeeding? The safety of Glucovance 250/1.25mg Tablet during pregnancy or breastfeeding has not been fully established. Consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
5. What should I do if I miss a dose of Glucovance 250/1.25mg Tablet? If you miss a dose of Glucovance 250/1.25mg Tablet, take it as soon as you remember, with food. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.