Uperio 100mg Tablet

Uperio 100mg Tablet is a combination medication that contains two active ingredients: Sacubitril & Valsartan. It is primarily used for the treatment of heart failure with reduced ejection fraction (HFrEF). Sacubitril is a neprilysin inhibitor, while valsartan is an angiotensin II receptor blocker (ARB). This combination medication works by increasing levels of natriuretic peptides and blocking the effects of angiotensin II, resulting in vasodilation and reduced blood pressure.

Active Ingredients:

• Sacubitril: Sacubitril is a neprilysin inhibitor that prevents the breakdown of natriuretic peptides, such as atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). By inhibiting neprilysin, sacubitril increases the levels of these peptides, leading to vasodilation, diuresis, and natriuresis.
• Valsartan: Valsartan is an angiotensin II receptor blocker (ARB) that blocks the effects of angiotensin II on its receptors, resulting in vasodilation and reduced aldosterone secretion. This leads to a decrease in blood pressure and preload on the heart.

Mechanism of Action:

Uperio 100mg Tablet works through two complementary mechanisms:

1. Sacubitril increases the levels of natriuretic peptides, which promote vasodilation, diuresis, and natriuresis, thereby reducing blood pressure and preload on the heart.
2. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to further vasodilation and reduction in blood pressure.

Uses:

Uperio 100mg Tablet is indicated for the treatment of heart failure with reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death and hospitalization for heart failure.

Dosage and Administration:

The recommended dosage of Uperio 100mg Tablet is one tablet taken orally twice daily. Dosage adjustments may be necessary based on individual patient response and tolerability.

Side Effects:

Common side effects of Uperio 100mg Tablet may include:

• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels)
• Renal impairment
• Dizziness
• Fatigue
• Cough
• Angioedema

Precautions:

• Uperio 100mg Tablet should not be used in patients with a history of angioedema related to previous angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) therapy.
• Patients should be monitored for hypotension, hyperkalemia, and renal function during treatment with Uperio.
• Concomitant use of Uperio with other potassium-sparing diuretics, potassium supplements, or medications that increase potassium levels should be avoided.

Conclusion:

Uperio 100mg Tablet containing sacubitril and valsartan is an effective combination medication for the treatment of heart failure with reduced ejection fraction (HFrEF). By targeting both the neprilysin pathway and the renin-angiotensin-aldosterone system (RAAS), Uperio helps improve cardiovascular outcomes and reduce the risk of hospitalization for heart failure in patients with HFrEF.