Uperio Fct 50mg 24/26mg Tablet

Uperio Fct 50mg/24/26mg Tablet is a medication containing a combination of Sacubitril & Valsartan as its active ingredients. It is used in the treatment of heart failure with reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death and hospitalization for heart failure. This combination medication works by enhancing the effects of natriuretic peptides while also blocking the angiotensin II receptor, resulting in vasodilation and decreased blood pressure.

Active Ingredients:

1. Sacubitril: Sacubitril is a neprilysin inhibitor that works by inhibiting the breakdown of natriuretic peptides, such as atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). These peptides promote vasodilation, natriuresis, and diuresis, leading to improved cardiac function and reduced fluid retention.
2. Valsartan: Valsartan is an angiotensin II receptor blocker (ARB) that blocks the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. By blocking the angiotensin II receptor, valsartan causes vasodilation and reduces blood pressure, thereby decreasing the workload on the heart.

Uses:

Uperio Fct 50mg/24/26mg Tablet is indicated for the treatment of:

• Heart failure with reduced ejection fraction (HFrEF) in adult patients to reduce the risk of cardiovascular death and hospitalization for heart failure.

Mechanism of Action:

The combination of Sacubitril and Valsartan in Uperio Fct Tablet works synergistically to:

• Increase the levels of natriuretic peptides, which promote vasodilation, natriuresis, and diuresis, leading to improved cardiac function and reduced fluid retention.
• Block the angiotensin II receptor, resulting in vasodilation, decreased blood pressure, and reduced workload on the heart.

Administration:

Uperio Fct 50mg/24/26mg Tablet is taken orally, usually once or twice daily with or without food, as directed by a healthcare professional. The dosage may be adjusted based on individual patient response and tolerability.

Side Effects:

Common side effects of Uperio Fct 50mg/24/26mg Tablet may include:

• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels)
• Renal impairment
• Dizziness
• Cough
• Fatigue

Precautions:

• Monitor blood pressure, renal function, and electrolyte levels regularly during treatment with Uperio Fct Tablet.
• Use caution in patients with a history of angioedema, renal impairment, or hyperkalemia.
• Avoid concomitant use of potassium-sparing diuretics, potassium supplements, or other medications that increase potassium levels.
• Inform healthcare providers about all current medications, including over-the-counter drugs and supplements, before starting Uperio Fct Tablet.

Contraindications:

Uperio Fct 50mg/24/26mg Tablet is contraindicated in patients with a history of angioedema related to previous angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) therapy. It should not be used during pregnancy or breastfeeding.